IGNOU MZO 008 SOLVED ASSIGNMENT

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MZO 008 2025 - English

ASSIGNMENT

Course Code: MZO-008

Assignment Code: MZO-008/TMA/2025

Maximum Marks: 100

Note: Attempt all questions. The marks for each question are indicated against it.

1.

a) What is IgM antibody. Discuss the functional importance of IgM.

b) Explain the concept of antigens and their classification as foreign or self-antigens.

2. Differentiate between the following pairs of terms:

a) Classical Pathway and Alternative Pathway of complement activation

b) B cell receptor (BCR) and T cell receptor (TCR)

c) Active Immunization and Passive Immunization

d) Primary Immunodeficiency (PID) and Secondary Immunodeficiency

3. Write short notes on the following:

a)

Ouchterlony Double Diffusion

b)

Superantigens

c)

Anaphylaxis

d)

Immunosuppressive Therapy

4. a)

Define the term "chimeric antibodies" and discuss their applications.

b) Explain Edward Jenner contributed to the development of vaccines?

5.

Describe the role of the bone marrow in the immune system, focusing on its structure and the process of hematopoiesis.

6.

a)

Define autoimmunity and discuss its role in immune system dysfunction.

b)

Explain how Gell and Coombs classified hypersensitivity reactions.

7.

a)

Describe the process of complement-induced lysis through MAC formation.

b) Briefly. describe the autocrine, paracrine, and endocrine functions of cytokines

8.

a) Discuss the pathways for processing both endogenous and exogenous antigens.

b) Explain the peptide-binding properties of Class I and II MHC molecules with a suitable diagram.

9.

a) Discuss the flow cytometry principles and its components.

b) Explain the DOT ELISA techniques and their working principles.

10. Explain the importance of donor and recipient matching in transplantation immunology, focusing on the role of human leukocyte antigen (HLA) typing and its impact on reducing graft rejection.

MZO 008 (January 2026 - July 2026) - ENGLISH

ASSIGNMENT

Course Code: MZO-008

Assignment Code: MZO-008/TMA/2026

Maximum Marks: 100

Note: Attempt all questions. The marks for each question are indicated against it.

1.

a) Describe the structure and function of thymus.

b) Explain the role of toll like receptor in innate immunity.

2. Write short notes:

a) Therapeutic vaccines

b) Superantigens

c) Natural Killer Cells.

d) ELISA

3.

a) How monoclonal antibodies are typically produced using hybridoma technology?

b) Write a note on the factors that influences immunogenicity.

4.

a) Illustrate structure and functions of primary lymphoid organs.

b) How do DNA vaccines work, and what are their potential advantages over traditional vaccines?

5.

a) Explain the classical pathway of complement system.

b) Explain in detail about endocytic pathways of antigen processing and presentation.

6.

a) Discuss the mechanism of immune response to viral infection.

b) Describe the steps involved in immunoelectrophoresis technique.

7.

a) Write a brief note on HLA tissue typing.

b) Discuss in detail about activation, maturation and differentiation of B-cells.

8.

a) Explain in detail about the mechanisms of antigen processing and presentation.

b) Explain in detail about different types of hypersensitivity reactions.

9.

a) Describe the structure and function of MHC molecules

b) Describe the properties and functions of cytokines.

10.

a) Discuss the causes of autoimmune disease in human.

b) Give a detailed account on the mechanism of phagocytosis.

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